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Obstacles and opportunities in the functional analysis of ...
These EV may differ in surface characteristics, possibly due to binding of lipid or protein moieties present in tissues or body fluids to the EV membrane. This may influence functional RNA transfer in destination cells, e.g. due to changes in EV binding to docking proteins or in the delivery of EV cargo through endosomal escape or direct ...
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In addition, once in the circulation, understanding is limited of EV half-life, of the mechanisms underlying distribution, of uptake of EVs into target tissues from bodily fluids and of tissue ...
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Role of extracellular vesicles in tumour microenvironment
Theoretically speaking, EVs can be classified [30] as either: (1) exosomes (Exos), which are small membrane vesicles (30–100 nm in diameter) derived from the endosome–multi-vesicular bodies (MVBs) pathway; or (2) microvesicles (MVs), which are large membrane vesicles (100–1000 nm diameter) budding away from the plasma membrane.
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One of the most prominent examples of such natural carriers are extracellular vesicles (EVs). EVs are cell-derived membranous particles which play important roles in intercellular communication. EVs possess a number of characteristics that qualify them as promising vehicles for drug delivery.
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